Circ_0030998 promotes tumor proliferation and angiogenesis by sponging miR-567 to regulate VEGFA in colorectal cancer

Abstract Colorectal cancer (CRC) is one of the most common malignancies worldwide. Circular RNAs (circRNAs) are involved in pathological processes, especially development cancers, but roles circRNAs CRC largely unknown. In this study, we investigated role and underlying mechanisms Circ_0030998 cell proliferation angiogenesis. We found that was upregulated tissues cells, its upregulation related to poor prognosis patients. promoted vitro vivo, facilitated angiogenesis HUVECs. Mechanistic studies demonstrated acted as a miR-567 sponge relieve inhibitory effect on VEGFA. Rescue assays validated functioned relying Our findings clarified Circ_0030998/miR-567/VEGFA regulation axis indicated could be potential therapeutic target for CRC.